Four US presidents never had a vice president.

https://historyfacts.com/us-history/fact/four-u-s-presidents-never-had-a-vice-president/?email=missphyuphyuthant%40gmail.com&sub_level=L1&sub_source=email_daily&utm_campaign=2251323704&utm_content=email_daily%20P1_headline&utm_medium=email&utm_source=16149490 

A president without a vice president is like a captain without a first mate, but some U.S. presidents — four, to be precise — have nevertheless had to serve without one. They were John Tyler (1841-1845), Millard Fillmore (1850-1853), Andrew Johnson (1865-1869), and Chester A. Arthur (1881-1885), all of whom ascended to the presidency when their predecessors died in office. Because the 25th Amendment didn’t lay out an official process for naming a new VP in such an event until 1967, those four commanders in chief simply went without one. All four failed to win reelection; some even failed to secure their party’s nomination and therefore never had the chance to select a running mate.